Browsing by Author "Jackie K Obey"

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    IN VITRO ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACT OF PITTOSPORUM VIRIDIFLORUM LEAVES EXTRACT AGAINST LABORATORY STRAINS OF SELECTED MICROORGANISMS
    (International Journal of Bioassays, 2014-08-08) Anthoney Swamy T; Jackie K Obey; Terer Erick Kipngetich; Miyogo Edwin
    The aim of this study was to analyse the antibacterial Activity of Pittosporum viridiflorum leaves extract against laboratory strains of selected microorganisms. Infusions of the bark of P. viridiflorum are used to treat stomach complaints, chest pain, malaria and other fever. The mean zones of inhibition of the extract against microorganisms were 12.67±0.882 mm for Enterobacter aerogenes, 12.50±0.281mm for Escherichia coli, 11.67±0.333 mm for Proteus vulgaris, 11.67±0.000mm for Bacillus cereus and 7.67±0.333mm for Salmonella typhi. The penicillin positive control showed large zones of inhibition and the dimethylsulfoxide negative control did not show any zone of inhibition. This report suggests that the extract was active against all the other organisms except S. typhi because the zone of inhibitions was less than 8 mm. Analysis of variance showed that the zones of inhibition of the extract and antibiotic control against the microorganisms were significantly different (p<0.0001). The Tukey’s honestly test further showed both significant and non-significant comparisons between the extract and controls for various bacterial organisms. This study has shown that controlling the growth of microorganisms in vitro can be achieved by the ethanolic extract of P. viridiflorum.
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    IN VITRO CONTROL OF SELECTED PATHOGENIC ORGANISMS BY METHANOLIC-AQUA EXTRACT OF ACANTHOSPERMUM AUSTRALE LEAVES
    (International Journal of Pharmaceutical Research & Analysis, 2014) Ngule Chrispus Mutuku; Jackie K Obey; Anthoney Swamy T
    The current study was done to analyse the antibacterial activity of the methanolic- aqua extract of Acanthospermum australe. From the study, the plant was found to inhibit only Bacillus cereus (20.00± 0.000) among all the other organisms the plant was tested against. Penicillin inhibited the growth of all the organisms while dimethyl sulfoxide (DMSO) did not show any zones of inhibition. The study shows that the plant can be used to treat against infections caused by Bacillus cereus, however; more research needs to be done to isolate the active compounds, determine their structural composition and their mode action in inhibiting the bacteria.