Mueni Hellen NdikuMutuku Chrispus Ngule2024-12-092024-12-092014-080976-7126https://ir.ueab.ac.ke/handle/123456789/297Nature is a paradise of medicinal solutions to all ailments affecting human beings. Medicinal plants have been used widely to treat against the currently widespread strains of drug resistant bacteria. Green medicine has attracted great interest due to the belief that it is safe, cheap and more dependable than aliphatic drugs, which have adverse side effects. The current study was done to analyze the Phytochemical and antibacterial activity of hot – aqua extract of Tetradenia riparia leaves. The Phytochemical results showed the plant to contain very important compounds (Table 1). The infused plant extract (Table 2) inhibited the growth of all the microorganisms tested. Bacillus cereus was the microorganism which had the highest zone of inhibition of 22.67± 0.453, followed by Serratia liquefaciens with an inhibition zone of 21.00±0.577, Enterobacter aerogenes inhibition zone of 14.33±0.333, Salmonella typhi, 13.33±0.333 and Escherichia coli, 13.33±0.887. Penicillin which was used as the positive control inhibited all the microorganisms while dimethyl sulfoxide (DMSO) which was used was used as the negative control did not show any zones of inhibition against the microorganisms used in the study. The results obtained in this study shows that the plant’s potency in the treatment against all the bacterial organisms tested. However further research needs to be done to isolate the active compounds, determine their structure, their mode of action and their effect in the in vivo environment.en-USArticle